期刊論文
| 學年 | 98 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2009-12-01 |
| 作品名稱 | Profiling time course expression of virus genes - An illustration of Bayesian inference under shape restrictions |
| 作品名稱（其他語言） | |
| 著者 | Chien, Li-Chu; Chang, I-Shou; Jiang, Shih-Sheng; Gupta, Pramod K.; Wen, Chi-Chung; Wu, Yuh-Jenn; Hsiung, Chao A. |
| 單位 | 淡江大學數學學系 |
| 出版者 | Beachwood: Institute of Mathematical Statistics |
| 著錄名稱、卷期、頁數 | The Annals of Applied Statistics 3(4), pp.1542-1565 |
| 摘要 | There have been several studies of the genome-wide temporal transcriptional program of viruses, based on microarray experiments, which are generally useful in the construction of gene regulation network. It seems that biological interpretations in these studies are directly based on the normalized data and some crude statistics, which provide rough estimates of limited features of the profile and may incur biases. This paper introduces a hierarchical Bayesian shape restricted regression method for making inference on the time course expression of virus genes. Estimates of many salient features of the expression profile like onset time, inflection point, maximum value, time to maximum value, area under curve, etc. can be obtained immediately by this method. Applying this method to a baculovirus microarray time course expression data set, we indicate that many biological questions can be formulated quantitatively and we are able to offer insights into the baculovirus biology. |
| 關鍵字 | Baculovirus; Bernstein polynomials; genome-wide expression profile; Markov chain Monte Carlo; microarray experiments; shape restricted regression |
| 語言 | en |
| ISSN | 1932-6157 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | 紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/53533 ) |