期刊論文
| 學年 | 101 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2013-06-01 |
| 作品名稱 | Hypoxanthine-Guanine Phosphoribosyl-Transferase Gene Mutation in Oral Cancer Patients Treated with Radiotherapy |
| 作品名稱（其他語言） | |
| 著者 | Chen, Hong-Wen; Hsu, Fei-Ting; Chang, Yue-Cune; Tu, Hsi-Feng; Fang, Chun-Kai; Kuo, Shu-Ping; Hwang, Jeng-Jong |
| 單位 | 淡江大學數學學系 |
| 出版者 | 臺北市：臺灣調適科學會 |
| 著錄名稱、卷期、頁數 | 調適醫學=Adaptive Medicine 5(2)，頁83-91 |
| 摘要 | Effect of ionizing radiation on the hypoxanthine-guanine phosphoribosyl-transferase (HPRT) gene in the peripheral lymphocytes of patients with oral cancer was studied. Subjects were randomly separated into five groups: A) healthy subjects without smoking and betel quid chewing habits; B) are healthy non-smokers but with betel quid chewing habit. Patients with oral cancer are all smokers and betel quid users, and are separated into three groups: pre-, during, and six months after radiotherapy (RT), respectively. The HPRT variant frequencies (Vfs) of groups A and B are (8.68 ± 2.1) × 10^(-6) and (9.48 ± 3.73) × 10^(-6), respectively. Notably, Vfs are (10.02 ± 2.68) × 10^(-6), (92.75 ± 17.48) × 10^(-6) and (61.72 ± 16.65) × 10^(-6), respectively, for groups C, D, and E. Both during- and post-RT groups demonstrate a significantly higher HPRT Vf as compared with that of pre-RT (P < 0.01). The effect of gender on HPRT Vf was also found in post-RT group (P < 0.05). In conclusion, oral cancer patients treated with RT resulted in the increase of HPRT gene mutation during and even six months post the treatment. |
| 關鍵字 | HPRT;oral cancer;radiotherapy;variant frequency |
| 語言 | en |
| ISSN | 2076-944X |
| 期刊性質 | 國內 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 是 |
| 國別 | TWN |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/93107 ) |