期刊論文
| 學年 | 98 |
|---|---|
| 學期 | 2 |
| 出版（發表）日期 | 2010-06-01 |
| 作品名稱 | Synthesis and characterization of stimuli-responsive porous/hollow nanoparticles by self-assembly of chitosan-based graft copolymers and application in drug release |
| 作品名稱（其他語言） | |
| 著者 | Chuang, Chung-Yang; Don, Trong-Ming; Chiu, Wen-Yen |
| 單位 | 淡江大學化學工程與材料工程學系 |
| 出版者 | Hoboken: John Wiley & Sons, Inc. |
| 著錄名稱、卷期、頁數 | Journal of Polymer Science Part A: Polymer Chemistry 48(11), pp.2377–2387 |
| 摘要 | In this research, stimuli-responsive porous/hollow nanoparticles were prepared by the self-assembly method. First, chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymers were synthesized through polymerization of N-isopropylacrylamide (NIPAAm) monomer in the presence of chitosan (CS) solution using ceric ammounium nitrate as the initiator. Then, the CS-g-PNIPAAm copolymers were dissolved in the acetic acid aqueous solution and heated to 40 °C to induce their self-assembly. After CS-g-PNIPAAm assembled to form micelles, a cross-linking agent was used to reinforce the structure to form nanoparticles. The molecular weight of grafted PNIPAAm on CS chains was changed to investigate its effect on the structure, morphology, thermo-, and pH-responsive properties of the nanoparticles. TEM images showed that a porous or hollow structure in the interior of nanoparticles was developed, depending on the medium temperature. The synthesized nanoparticles carried positive charges on the surface and exhibited stimuli-responsive properties, and their mean diameter thus could be manipulated by changing the pH value and temperature of the environment. The nanoparticles showed a continuous release of the encapsulated doxycycline hyclate up to 10 days during an in vitro release experiment. These porous/hollow particles with environmentally sensitive properties are expected to be used in hydrophilic drug delivery system. |
| 關鍵字 | graft copolymers; nanoparticles; polysaccharides; self-assembly; stimuli-response |
| 語言 | en |
| ISSN | 1099-0518 |
| 期刊性質 | 國外 |
| 收錄於 | SCI EI |
| 產學合作 | |
| 通訊作者 | Chiu, Wen-Yen |
| 審稿制度 | |
| 國別 | USA |
| 公開徵稿 | |
| 出版型式 | 電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/60172 ) |