期刊論文
| 學年 | 97 |
|---|---|
| 學期 | 1 |
| 出版（發表）日期 | 2008-10-01 |
| 作品名稱 | Epstein–Barr virus infection and plasma transforming growth factor-β1 levels in head and neck cancers |
| 作品名稱（其他語言） | |
| 著者 | Chen, Hong-wen; Yang, Sheau-fang; 張玉坤; Cheng, Yue-cune; Wang, Tao-yeung; Chen, Yu-jen; Lai, Yuen-liang |
| 單位 | 淡江大學數學學系 |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Acta Oto-Laryngologica 18, pp.1145-1151 |
| 摘要 | Conclusions. In addition to the correlation of transforming growth factor (TGF)-β1 levels to the radiation toxicity, both Epstein–Barr virus (EBV) infection and postoperative status play roles in the change in plasma TGF-β1 levels in patients with head and neck cancers. Objectives. To assess the parameters involved in the change in plasma TGF-β1 level during concurrent chemoradiotherapy (CCRT). Patients and methods. Blood samples (n=307) before, during, and after treatment were obtained from 39 patients with head and neck cancers treated with definitive or adjuvant CCRT. In situ hybridization (ISH) was used to identify EBV-encoded RNA (EBER) in tissues from the primary tumor or metastatic lymph nodes. Plasma TGF-β1 level, white blood cell (WBC), and platelet count were assayed immediately before the first fraction of radiotherapy (RT), once a week during RT, and at the end of the RT course. The grades of mucositis and dermatitis were recorded weekly during CCRT. Results. Pretreatment TGF-β1 level and radiation toxicity were found to be significantly correlated with the increase of the plasma TGF-β1 level during CCRT (p<0.05), but correlation of platelet count was only found in patients whose tumors were EBV-positive (p=0.0042), and WBC count in those treated with postoperative adjuvant CCRT (p=0.004). |
| 關鍵字 | EBW;transforming growth factor-β1(TGf-β1; head and neck cancer;CCRT |
| 語言 | en |
| ISSN | |
| 期刊性質 | 國內 |
| 收錄於 | |
| 產學合作 | |
| 通訊作者 | |
| 審稿制度 | 否 |
| 國別 | TWN |
| 公開徵稿 | |
| 出版型式 | ,電子版 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/58729 ) |